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), trijodotyronin (T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 )) 
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\hich\af1\dbch\af36\loch\f1 Om hormonene:
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\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 4}{\f1\fs36\insrsid9045379 
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\par }{\f1\fs44\insrsid9045379 \bullet }{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  Begge dannes ved sammenkobling av 2 jodinerte
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\par \hich\af1\dbch\af36\loch\f1  \tab tyroglobulin)
\par 
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\hich\af1\dbch\af36\loch\f1 1) stort opptak av jodid (I}{\f1\fs32\super\insrsid9045379 \hich\af1\dbch\af36\loch\f1 -}{\f1\fs32\insrsid9045379 \hich\af1\dbch\af36\loch\f1 ) i skjoldbruskkjertelceller
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\hich\af1\dbch\af36\loch\f1 kan anvendes i klinisk sammenheng
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\hich\af1\dbch\af36\loch\f1 \hich\f1 2) syntese av tyroglobulin (660 kD) intracellul\'e6\loch\f1 \hich\f1 rt, s\'e5
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\hich\af1\dbch\af36\loch\f1 frijort til follikkellumen. Har ca. 140 tyrosiner.
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\hich\af1\dbch\af36\loch\f1 3) TPO (tyrosin peroksidase): oksidering av jodid og
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\hich\af1\dbch\af36\loch\f1 4) sammenkobling av jodinerte tyrosiner (TPO)}{\f1\fs36\insrsid9045379 
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\hich\af1\dbch\af36\loch\f1 endocytert, proteolytisk nedbrytning til T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 4}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  og T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3}{
\f1\fs36\insrsid9045379 
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\par }{\f1\fs44\insrsid9045379 \bullet }{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  Extra-thryoideale lager (33% i lever og nyrene)
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\par 
\par }{\f1\fs44\insrsid9045379 \bullet }{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  Ca. 20 ganger mer T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 4}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  enn T}{
\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3
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\hich\af1\dbch\af36\loch\f1 4}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  ved spalting av jod
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\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  i serum bundet til bindingsproteiner (viktigst: TBG)
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\par }{\f1\fs44\insrsid9045379 
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\par 
\par \tab \hich\af1\dbch\af36\loch\f1 jodid-\hich\af1\dbch\af36\loch\f1 opptak
\par \tab \hich\af1\dbch\af36\loch\f1 TPO aktivitet
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\f1\fs36\insrsid9045379 
\par \tab \hich\af1\dbch\af36\loch\f1 binding til bindingsproteiner
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\par \page 
\par 
\par 
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\hich\af1\dbch\af36\loch\f1 Virkninger:
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\par \bullet }{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3 }{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 virker via reseptorer i kjernen og i mitochondria
\par \tab \hich\af1\dbch\af36\loch\f1 reseptorene er transkripsjonsfaktorer
\par 
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\hich\af1\dbch\af36\loch\f1 mange forskjellige ef\hich\af1\dbch\af36\loch\f1 fekter, bl.a.:
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\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  stimulerer varmeproduksjon
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\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  regulerer stoffskifte
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\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 \hich\f1  n\'f8\loch\f1 dvendig for normal lengdevekst
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\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 \hich\f1  n\'f8\loch\f1 dvendig for normal utvikling av nervesystemet
\par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\f1\fs36\insrsid9045379 \tab 
\par \tab }{\f1\fs44\insrsid9045379 \bullet }{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 \hich\f1  \'f8\loch\f1 ker det sympatiske nervesystemets virkning
\par \tab \tab \hich\af1\dbch\af36\loch\f1 (}{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 antall adrenerge reseptorer)
\par 
\par \tab }{\f1\fs44\insrsid9045379 \bullet }{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  vedlikeholder aksonenes impulsledningshastighet 
\par 
\par }\pard \ql \fi720\li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\f1\fs36\insrsid9045379 
\par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid9045379 
\par 
\par 
\par 
\par 
\par 
\par }\pard \ql \li0\ri-435\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-435\lin0\itap0 {\f1\fs48\insrsid9045379 \hich\af1\dbch\af36\loch\f1 Regulering av TSH sekresjon:
\par }{\f1\fs36\insrsid9045379 
\par }\pard \ql \li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 {\f1\fs36\insrsid9045379 
\par \hich\af1\dbch\af36\loch\f1 TSH seseneres av thyrotropene i forlappen
\par 
\par \hich\af1\dbch\af36\loch\f1 TSH sekresjon regulert av intracellular T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  konsentrasjon i thyrotropene
\par 
\par \hich\af1\dbch\af36\loch\f1 80% av T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  i thyro\hich\af1\dbch\af36\loch\f1 tropene kommer fra in situ deiodinering av T}{
\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 4}{\f1\fs36\insrsid9045379 
\par 
\par \hich\af1\dbch\af36\loch\f1 dermed er T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 \hich\f1  intracellul\'e6\loch\f1 rt avhengig av transport og deiodinering av T}{
\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 4}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 , og TSH sekresjon kan reguleres tildels via regulering av serum T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 4}{
\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 \hich\f1  niv\'e5\loch\f1 er og av deiodineringsenzymet
\par 
\par }\pard \ql \li0\ri-435\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-435\lin0\itap0 {\f1\fs36\insrsid9045379 
\par }\pard \ql \li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 {\f1\fs36\insrsid9045379 
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 TSH sekresjon ogs\'e5\loch\f1  regulert av TR\hich\af1\dbch\af36\loch\f1 H
\par 
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 thyrotropenes f\'f8\loch\f1 \hich\f1 lsomhet for TRH ogs\'e5\loch\f1  regulert av intracellular T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 
 konsentrasjon
\par 
\par \tab }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ad}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1   }{
\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ae\'20\'20\'af\'20}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 TRH reseptorer  }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ae\'20\'20\'af\'20}{\f1\fs36\insrsid9045379 
\hich\af1\dbch\af36\loch\f1 TSH sekresjon
\par 
\par \tab \tab \hich\af1\dbch\af36\loch\f1 (dette er situasjonen ved }{\f1\fs36\ul\insrsid9045379 \hich\af1\dbch\af36\loch\f1 hyper}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 thyroidisme)
\par 
\par \tab }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'af}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 3}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1   }{
\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ae\'20\'20\'ad\'20}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 TRH reseptorer  }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ae\'20\'20\'ad\'20}{\f1\fs36\insrsid9045379 
\hich\af1\dbch\af36\loch\f1 TSH sekresjon
\par 
\par \tab \tab \hich\af1\dbch\af36\loch\f1 (dette er situasjonen ved }{\f1\fs36\ul\insrsid9045379 \hich\af1\dbch\af36\loch\f1 hypo}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 thyroidisme)
\par 
\par }\pard \ql \li0\ri-435\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-435\lin0\itap0 {\f1\fs36\insrsid9045379 
\par \page 
\par }\pard \ql \li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 {\f1\fs36\insrsid9045379 
\par }\pard\plain \s15\ql \li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 
\fs36\lang1044\langfe1033\loch\af1\hich\af1\dbch\af36\cgrid\langnp1044\langfenp1033 {\insrsid9045379 \hich\af1\dbch\af36\loch\f1 TSH stimulerer vekst og vaskulerisering av skjoldbruskkjertelen
\par }\pard\plain \ql \li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 
\fs24\lang1044\langfe1033\loch\af37\hich\af37\dbch\af36\cgrid\langnp1044\langfenp1033 {\f1\fs36\insrsid9045379 
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 Struma (hyperplasi av skjoldbruskkjertelen) kan v\'e6\loch\f1 re til stede enten ved hypothyroidisme, euthyroidisme, eller hyperthyroidisme
\par 
\par \tab \hich\af1\dbch\af36\loch\f1 hypothryoidisme (ved for lite I}{\f1\fs36\super\insrsid9045379 \hich\af1\dbch\af36\loch\f1 -}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 ):
\par \tab }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'af}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 4}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1   }{
\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ae\'20\'20\'ad\'20}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 TRH reseptorer  }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ae\'20\'20\'ad\'20}{\f1\fs36\insrsid9045379 
\hich\af1\dbch\af36\loch\f1 TSH sekresjon
\par }\pard \ql \fi720\li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 {\f1\fs36\insrsid9045379 
\hich\af1\dbch\af36\loch\f1  (struma)
\par }\pard \ql \li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 {\f1\fs36\insrsid9045379 
\par \tab \hich\af1\dbch\af36\loch\f1 euthyroidisme:
\par \tab }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 TSH sekresjon\hich\af1\dbch\af36\loch\f1  (struma) }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ae\'20\'20\'ad\'20}{
\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 I}{\f1\fs36\super\insrsid9045379 \hich\af1\dbch\af36\loch\f1 -}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  opptak 
\par }\pard \ql \fi720\li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 {\f3\fs36\insrsid9045379 
\loch\af3\dbch\af36\hich\f3 \'ae\'20}{\f1\fs36\insrsid9045379 \loch\af1\dbch\af36\hich\f1 \u-3986\'3f\u-3985\'3f\loch\f1 rmalisert T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 4
\par }\pard \ql \li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 {\f1\fs36\sub\insrsid9045379 
\par \tab }{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 hyperthyroidisme (ved Grave\hich\f1 \rquote \loch\f1 s sykdom):
\par \tab \hich\af1\dbch\af36\loch\f1 TSAb  }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ae\'20\'20\'ad}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  T}{\f1\fs36\sub\insrsid9045379 \hich\af1\dbch\af36\loch\f1 4}{\f1\fs36\insrsid9045379 
\hich\af1\dbch\af36\loch\f1  , og hermer TSH }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ae\'20\'20}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 struma
\par 
\par }\pard \ql \li0\ri-435\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-435\lin0\itap0 {\f1\fs36\insrsid9045379 
\par \page 
\par }\pard \ql \li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 {\f1\fs36\insrsid9045379 
\hich\af1\dbch\af36\loch\f1 Symptomer ved }{\f1\fs36\ul\insrsid9045379 \hich\af1\dbch\af36\loch\f1 hypo}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 thyroidisme:
\par 
\par \hich\af1\dbch\af36\loch\f1 hos foster/spebarn: hemmet vekst og mental utvikling
\par 
\par \hich\af1\dbch\af36\loch\f1 hos voksne:
\par 
\par }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'af}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  BMR
\par \hich\af1\dbch\af36\loch\f1 svakhet, treghet (musk\hich\af1\dbch\af36\loch\f1 \hich\f1 ul\'e6\loch\f1 rt)
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 s\'f8\loch\f1 vnighet, treghet (mentalt)
\par \hich\af1\dbch\af36\loch\f1 forlenget reflekslatenstider
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 t\'f8\loch\f1 rr, kald hud, }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'af}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1  svetting
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 overf\'f8\loch\f1 lsomhet for kulde
\par \hich\af1\dbch\af36\loch\f1 overvekt
\par \hich\af1\dbch\af36\loch\f1 myxedema
\par \hich\af1\dbch\af36\loch\f1 struma
\par \hich\af1\dbch\af36\loch\f1 heshet
\par \hich\af1\dbch\af36\loch\f1 amenorrhea
\par \hich\af1\dbch\af36\loch\f1 psykoser
\par \hich\af1\dbch\af36\loch\f1 forandringer i elektrokardiogram
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 tynt, skj\'f8\loch\f1 \hich\f1 rt h\'e5\loch\f1 r
\par \hich\af1\dbch\af36\loch\f1 forstoppelse
\par }\pard \ql \li0\ri-435\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-435\lin0\itap0 {\f1\fs36\insrsid9045379 
\par 
\par 
\par \page 
\par }\pard \ql \li0\ri-435\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-435\lin0\rtlgutter\itap0 {\f1\fs36\insrsid9045379 
\hich\af1\dbch\af36\loch\f1 Symptomer ved }{\f1\fs36\ul\insrsid9045379 \hich\af1\dbch\af36\loch\f1 hyper}{\f1\fs36\insrsid9045379 \hich\af1\dbch\af36\loch\f1 t\hich\af1\dbch\af36\loch\f1 hyroidisme:
\par 
\par }{\f3\fs36\insrsid9045379 \loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid9045379 \loch\af1\dbch\af36\hich\f1 \u-4030\'3f\u-4019\'3f\u-4014\'3f
\par \loch\af1\dbch\af36\hich\f1 \'f8\loch\f1 kt appetitt
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 nerv\'f8\loch\f1 sitet, tremor
\par \hich\af1\dbch\af36\loch\f1 forkortet reflekslatenstider
\par \hich\af1\dbch\af36\loch\f1 fuktig, varm hud
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 overf\'f8\loch\f1 lsomhet for varme
\par \hich\af1\dbch\af36\loch\f1 pretibial myxedema (v/Grave\hich\f1 \rquote \loch\f1 s sykdom)
\par \hich\af1\dbch\af36\loch\f1 struma
\par \loch\af1\dbch\af36\hich\f1 \'f8\loch\f1 \hich\f1 kt avf\'f8\loch\f1 ringsfrekvens
\par \hich\af1\dbch\af36\loch\f1 exophthalmos (v/Grave\hich\f1 \rquote \loch\f1 s sykdom)*
\par 
\par 
\par \hich\af1\dbch\af36\loch\f1 *Grave\hich\f1 \rquote \loch\f1 s sykdom er autoimmunt, me\hich\af1\dbch\af36\loch\f1 
d produksjon av antistoffer som hermer TSH. Exophthalmos kommer trolig av at retroorbitale fibroblaster og adipocytter har TSH reseptorer, og infiltrasjon av orbita med T-celler gir kraftig retroorbital edema.
\par }\pard \ql \li0\ri-435\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-435\lin0\itap0 {\f1\fs36\insrsid9045379 
\par }\pard \ql \li-993\ri-1050\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-1050\lin-993\itap0 {\f1\fs36\ul\insrsid9045379 
\par }\pard \ql \li0\ri-1333\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-1333\lin0\itap0 {\f1\fs36\ul\insrsid9045379 
\par }{\f1\fs36\insrsid9045379 
\par }}