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{\*\generator Microsoft Word 10.0.5522;}{\info{\title Veksthormon (growth hormone, somatotropin)}{\author Linda Tholfsen}{\operator Linda Tholfsen}{\creatim\yr2004\mo2\dy3\hr9\min55}{\revtim\yr2004\mo2\dy3\hr9\min55}{\printim\yr2001\mo9\dy4\min28}
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\ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 \fs24\lang1044\langfe1033\loch\af37\hich\af37\dbch\af36\cgrid\langnp1044\langfenp1033 {\insrsid5448724 
\par 
\par }{\b\f1\fs36\lang1033\langfe1033\langnp1033\insrsid5448724\charrsid5448724 \hich\af1\dbch\af36\loch\f1 Veksthormon }{\f1\fs36\lang1033\langfe1033\langnp1033\insrsid5448724\charrsid5448724 \hich\af1\dbch\af36\loch\f1 (growth hormone (GH), somatotropin) 

\par 
\par 
\par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\b\f1\fs36\insrsid5448724 
\hich\af1\dbch\af36\loch\f1 Om hormonet:
\par }{\f1\fs36\insrsid5448724 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  Peptidhormon (191 aminosyrer) som dannes av
\par \tab \hich\af1\dbch\af36\loch\f1 egne celler (somatotrope celler) i forlappen
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  ligner strukturelt prolaktin (199 a.s., 92% likt)
\par \hich\af1\dbch\af36\loch\f1  \tab (noe overlapp i virkning)
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  multiple form\hich\af1\dbch\af36\loch\f1 er i serum bundet til bindingsprotein
\par }\pard \ql \fi720\li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\f1\fs36\insrsid5448724 
\hich\af1\dbch\af36\loch\f1 \hich\f1 (fragment av GH-reseptor) som \'f8\loch\f1 ker halveringstid
\par \hich\af1\dbch\af36\loch\f1 (normalt 10-30 minutter)
\par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\f1\fs36\insrsid5448724 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  virker via tyrosin-kinase-reseptorer
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 \hich\f1  virkning ikke knyttet til ett bestemt m\'e5\loch\f1 lorgan
\par \tab \hich\af1\dbch\af36\loch\f1 \hich\f1 derimot p\'e5\loch\f1  de fleste vev i kroppen
\par \tab \hich\af1\dbch\af36\loch\f1 oftest via insuli\hich\af1\dbch\af36\loch\f1 n-lignende vekstfaktorer (IGFs)}{\f1\fs36\sub\insrsid5448724 
\par }{\f1\fs36\insrsid5448724 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  IGFs er:
\par \tab \hich\af1\dbch\af36\loch\f1 \hich\f1 mitogene p\'e5\loch\f1  chondrocytter og osteoblaster
\par \tab \hich\af1\dbch\af36\loch\f1 hermer insulin (parakrint, d.v.s. lokalt)
\par \tab \hich\af1\dbch\af36\loch\f1 stimulerer glukose og aminosyre opptak
\par \tab \hich\af1\dbch\af36\loch\f1 produsert i mange vev (obs: lever }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ae\'20}{\f1\fs36\insrsid5448724 \loch\af1\dbch\af36\hich\f1 \u-3981\'3f\u-3995\'3f\u-3982\'3f\u-3979\'3f\u-3987\'3f\loch\f1  IGF)

\par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid5448724 \page 
\par 
\par 
\par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\b\f1\fs36\insrsid5448724 
\hich\af1\dbch\af36\loch\f1 Virkninger:
\par }{\f1\fs36\insrsid5448724 \tab \tab }{\f1\fs44\insrsid5448724 
\par \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  stimulerer lengde\hich\af1\dbch\af36\loch\f1 \hich\f1 vekst fra f\'f8\loch\f1 dselen
\par 
\par \tab \hich\af1\dbch\af36\loch\f1 \hich\f1 (h\'f8\loch\f1 yeste verdier ved pubertet/ung voksen alder)
\par 
\par \tab \hich\af1\dbch\af36\loch\f1 mediert av IGFs produsert av chondrocytter
\par \tab \hich\af1\dbch\af36\loch\f1 (GH stimulerer differensiering av chondrocytter)
\par 
\par \tab \hich\af1\dbch\af36\loch\f1 \hich\f1 mangel p\'e5\loch\f1 \hich\f1  GH eller GH reseptorer for\'e5\loch\f1 rsaker
\par \tab }{\f1\fs36\chbrdr\brdrs\brdrw10 \insrsid5448724 \hich\af1\dbch\af36\loch\f1 dvergvekst}{\f1\fs36\insrsid5448724 
\par 
\par \tab \hich\af1\dbch\af36\loch\f1 \hich\f1 forh\'f8\loch\f1 \hich\f1 yet produksjon for\'e5\loch\f1 rsaker }{\f1\fs36\chbrdr\brdrs\brdrw10 \insrsid5448724 \hich\af1\dbch\af36\loch\f1 g\hich\af1\dbch\af36\loch\f1 igantism}{\f1\fs36\insrsid5448724 
\hich\af1\dbch\af36\loch\f1  eller 
\par \tab }{\f1\fs36\chbrdr\brdrs\brdrw10 \insrsid5448724 \hich\af1\dbch\af36\loch\f1 acromegaly}{\f1\fs36\insrsid5448724 
\par 
\par \tab \hich\af1\dbch\af36\loch\f1 Afrikanske }{\f1\fs36\chbrdr\brdrs\brdrw10 \insrsid5448724 \hich\af1\dbch\af36\loch\f1 pygmier}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 : mangler normal IGF-1 puls ved
\par \tab \hich\af1\dbch\af36\loch\f1 pubertet
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  stimulerer proteinsyntese (anabol virkning) 
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  stimulerer fett- og karbohydratstoffskifte
\par \tab \hich\af1\dbch\af36\loch\f1 og reduserer glukose opptak
\par 
\par \tab \hich\af1\dbch\af36\loch\f1 \hich\f1 derved \'f8\loch\f1 ker blodglukose (motvirker hypogl\hich\af1\dbch\af36\loch\f1 ycemi)
\par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid5448724 
\par 
\par 
\par 
\par 
\par 
\par 
\par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\b\f1\fs36\insrsid5448724 
\hich\af1\dbch\af36\loch\f1 Regulering av GH produksjon
\par }{\f1\fs36\insrsid5448724 
\par }{\f1\fs56\insrsid5448724 \hich\af1\dbch\af36\loch\f1 +}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  GH-stimulerende hormon (GH-RH) 
\par 
\par }{\f1\fs56\insrsid5448724 \hich\af1\dbch\af36\loch\f1 +}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  dopamin (stimulerer GH-RH)
\par 
\par }{\b\f3\fs56\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'b8}{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'20\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 \hich\f1 G\u-4024\'3f\loch\f1 -hemmende hormon (GH-IH, somatostatin) 
\par 
\par }{\b\f3\fs56\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'b8}{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'20\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 IGF-1 fra leveren
\par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid5448724 
\par 
\par \page 
\par 
\par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\b\f1\fs36\insrsid5448724 
\hich\af1\dbch\af36\loch\f1 Hva stimulerer GH sekresjon?
\par }{\f1\fs36\insrsid5448724 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  hypoglykemi
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 \hich\f1 serum aminosyrer (s\'e6\loch\f1 rlig ar
\hich\af1\dbch\af36\loch\f1 ginin, leucin)
\par 
\par }{\f1\fs44\lang1033\langfe1033\langnp1033\insrsid5448724\charrsid5448724 \bullet }{\f1\fs36\lang1033\langfe1033\langnp1033\insrsid5448724\charrsid5448724 \hich\af1\dbch\af36\loch\f1  TRH
\par 
\par }{\f1\fs44\lang1033\langfe1033\langnp1033\insrsid5448724\charrsid5448724 \bullet }{\f1\fs36\lang1033\langfe1033\langnp1033\insrsid5448724\charrsid5448724 \hich\af1\dbch\af36\loch\f1  stress, ADH, glucagon
\par 
\par }{\f1\fs44\lang1033\langfe1033\langnp1033\insrsid5448724\charrsid5448724 \bullet }{\f1\fs36\lang1033\langfe1033\langnp1033\insrsid5448724\charrsid5448724 \hich\af1\dbch\af36\loch\f1  dopamin agonister
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 \hich\f1  mosjon, s\'f8\loch\f1 vn (stadier III og IV), pubertet
\par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid5448724 
\par 
\par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\b\f1\fs36\insrsid5448724 
\hich\af1\dbch\af36\loch\f1 Hva hemmer GH sekresjon?
\par }{\f1\fs36\insrsid5448724 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  hyperglykemi
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  hypothyroidisme
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  dopamin antagonister
\par 
\par }{\f1\fs44\insrsid5448724 \bullet }{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 \hich\f1  f\'f8\loch\f1 lelsesmessig-deprivasjon hos barn, aldring
\par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid5448724 
\par 
\par 
\par 
\par 
\par 
\par }\pard \ql \li-993\ri-1050\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-1050\lin-993\itap0 {\b\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 Sa\hich\af1\dbch\af36\loch\f1 mspill med insulin:
\par }{\f1\fs36\insrsid5448724 
\par \hich\af1\dbch\af36\loch\f1 \hich\f1 GH kan ikke stimulere IGF i frav\'e6\loch\f1 r av insulin
\par 
\par }\pard \ql \li-993\ri-1050\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-1050\lin-993\rtlgutter\itap0 {\f1\fs36\ul\insrsid5448724 
\hich\af1\dbch\af36\loch\f1 \hich\f1 god, balansert ern\'e6\loch\f1 ring}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 :
\par 
\par }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ad}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  aminosyrer  \tab }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ae}{\f1\fs36\insrsid5448724 \tab }{\f3\fs36\insrsid5448724 
\loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 GH\tab \tab \tab 
\par \tab \tab \tab \tab \tab \tab \tab \hich\af1\dbch\af36\loch\f1   \tab }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 IGF, vekst fremmet 
\par }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ad}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  glukose\tab \tab }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ae}{\f1\fs36\insrsid5448724 \tab }{\f3\fs36\insrsid5448724 
\loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 insulin
\par 
\par }\pard \ql \li-993\ri-1050\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-1050\lin-993\itap0 {\f1\fs36\insrsid5448724 
\par 
\par }\pard \ql \li-993\ri-1050\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-1050\lin-993\rtlgutter\itap0 {\f1\fs36\ul\insrsid5448724 
\hich\af1\dbch\af36\loch\f1 \hich\f1 h\'f8\loch\f1 y karbohydrat, lav protein}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 :
\par 
\par }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'af}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  aminosyrer  \tab }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ae}{\f1\fs36\insrsid5448724 \tab }{\f3\fs36\insrsid5448724 
\loch\af3\dbch\af36\hich\f3 \'af\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 GH\tab \tab \tab 
\par \tab \tab \tab \tab \tab \tab \tab \hich\af1\dbch\af36\loch\f1   \tab }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'af\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 IGF, vekst hemmet 
\par }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ad}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  glukose\tab \tab }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ae}{\f1\fs36\insrsid5448724 \tab }{\f3\fs36\insrsid5448724 
\loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 insulin
\par 
\par }\pard \ql \li-993\ri-1050\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-1050\lin-993\itap0 {\f1\fs36\insrsid5448724 
\par 
\par }\pard \ql \li-993\ri-1050\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-1050\lin-993\rtlgutter\itap0 {\f1\fs36\ul\insrsid5448724 
\hich\af1\dbch\af36\loch\f1 sult}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 :
\par 
\par }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'af}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  glukose\tab \tab }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ae}{\f1\fs36\insrsid5448724 \tab }{\f3\fs36\insrsid5448724 
\loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 GH\tab \tab \tab 
\par \tab \tab \tab \tab \tab \tab \tab \hich\af1\dbch\af36\loch\f1   \tab }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'af\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 IGF, vekst hemmet 
\par }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'af}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1  glukose\tab \tab }{\f3\fs36\insrsid5448724 \loch\af3\dbch\af36\hich\f3 \'ae}{\f1\fs36\insrsid5448724 \tab }{\f3\fs36\insrsid5448724 
\loch\af3\dbch\af36\hich\f3 \'af\'20}{\f1\fs36\insrsid5448724 \hich\af1\dbch\af36\loch\f1 insulin
\par 
\par 
\par \hich\af1\dbch\af36\loch\f1 Her er GH hensiktsmessig fordi det fremmer fett-stoffskiftet og derved beskytter mot katabolisme av vevsprotein!
\par 
\par }\pard \ql \li-993\ri-1050\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-1050\lin-993\itap0 {\f1\fs36\ul\insrsid5448724 
\par }\pard \ql \li0\ri-1333\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-1333\lin0\itap0 {\f1\fs36\ul\insrsid5448724 
\par }{\f1\fs36\insrsid5448724 
\par }}