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Mangler enzymene for syntese av glukokortikoider og kj\loch\af1\dbch\af36\hich\f1 \'f8\loch\f1 nnshormoner. \par \par \hich\af1\dbch\af36\loch\f1 \hich\f1 De 2 indre lagene (zona fasiculata, zona reticularis) syntetiserer glukokortikoider. Zona reticularis syntetiserer i tillegg kj\'f8\loch\f1 nnshormoner. \par \par \hich\af1\dbch\af36\loch\f1 Ikke lagret \hich\f1 \endash \loch\f1 sekresjon reguleres ved syntese \par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid10887455 \par \par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 Glukokortikoider har funksjonell overlap med minera\hich\af1\dbch\af36\loch\f1 lokortikoider (interagerer med hverandres reseptorer) \par \par \hich\af1\dbch\af36\loch\f1 diffunderer igjennom cellemembranen og binder til kjernereseptorer som fungere som ligand-regulerte transkripsjonsfaktorer \par \par \hich\af1\dbch\af36\loch\f1 cortisol er mest kraftig naturlig glukokortikoid \par \par \hich\af1\dbch\af36\loch\f1 transportert i blodet bunde\hich\af1\dbch\af36\loch\f1 t til protein \par \tab \hich\af1\dbch\af36\loch\f1 (75% til transcortin, 15% til albumin) \par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid10887455 \par \par \par \par \par \par \par \par \par \par \par \par \par \par \par \par \par \par \par \par \par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\f1\fs48\insrsid10887455 \hich\af1\dbch\af36\loch\f1 Effekter av cortisol: \par }{\f1\fs36\insrsid10887455 \par }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 metabolsk \par }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 proteolysis \par \hich\af1\dbch\af36\loch\f1 gluconeogenesis \par }{\f3\fs36\insrsid10887455 \loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid10887455 \loch\af1\dbch\af36\hich\f1 \u-3998\'3f\u-3988\'3f\u-3985\'3f\u-3996\'3f\u-4064\'3f\u-3993\'3f\u-3988\'3f\u-3979\'3f\u-3989\'3f\u-3985\'3f\u-3981\'3f\u-3995\'3f \loch\f1 }{\f3\fs36\insrsid10887455 \loch\af3\dbch\af36\hich\f3 \'ae\'20}{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 }{\f3\fs36\insrsid10887455 \loch\af3\dbch\af36\hich\f3 \'ad\'20}{\f1\fs36\insrsid10887455 \loch\af1\dbch\af36\hich\f1 \u-3998 \'3f\u-3988\'3f\u-3985\'3f\u-3996\'3f\u-4064\'3f\loch\f1 insulin }{\f3\fs36\insrsid10887455 \loch\af3\dbch\af36\hich\f3 \'ae\'20}{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 lipogenesis \par \hich\af1\dbch\af36\loch\f1 stimulerer appetitt \par \par }{\f1\fs48\insrsid10887455 \bullet \hich\af1\dbch\af36\loch\f1 }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 hypercortisolisme medf\'f8\loch\f1 rer }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 overvekt}{ \f1\fs36\insrsid10887455 \par \tab \hich\af1\dbch\af36\loch\f1 (med uvanli\hich\af1\dbch\af36\loch\f1 \hich\f1 g m\'f8\loch\f1 nster \hich\f1 \endash \loch\f1 hvorfor?) \par \par \par }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 p\'e5\loch\f1 benvev \par }{\f3\fs36\insrsid10887455 \loch\af3\dbch\af36\hich\f3 \'af\'20}{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 kalsium opptak fra tarm \par }{\f3\fs36\insrsid10887455 \loch\af3\dbch\af36\hich\f3 \'af\'20}{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 kalsium reabsorpsjon i nyrene \par }{\f3\fs36\insrsid10887455 \loch\af3\dbch\af36\hich\f3 \'ad}{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 resorpsjon av ben \par \loch\af1\dbch\af36\hich\f1 \u-3992\'3f\u-3995\'3f\u-3987\'3f\u-3987\'3f\u-3995\'3f\u-3982\'3f\u-4064\'3f\u-3985\'3f\u-3981\'3f\u-3980\'3f\u-3995\'3f\u-3985\'3f\u-3998\'3f\u-3988\'3f\u-3999\'3f\u-3981\'3f\u-3980\'3f\u-3995\'3f\u-3982\'3f \par \par }{\f1\fs48\insrsid10887455 \bullet \hich\af1\dbch\af36\loch\f1 }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 hypercortisolisme medf\'f8\loch\f1 rer }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 osteoporose}{ \f1\fs36\insrsid10887455 \par \par \par }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 p\'e5\loch\f1 bindevev \par }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 hemmer fibroblast proliferasjon og kollagensyntese \par \hich\af1\dbch\af36\loch\f1 \hich\f1 bindevevsst\'f8\loch\f1 tte a\hich\af1\dbch\af36\loch\f1 v kapillarer \par \par }{\f1\fs48\insrsid10887455 \bullet \hich\af1\dbch\af36\loch\f1 }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 hypercortisolisme medf\'f8\loch\f1 rer }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 skj\'f8\loch\f1 \hich\f1 r hud, bl\'e5\loch\f1 merker}{\f1\fs36\insrsid10887455 \par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid10887455 \par \par \par \par \par \par \par }\pard \ql \li0\ri-766\widctlpar\brdrt\brdrs\brdrw10\brsp20 \brdrl\brdrs\brdrw10\brsp80 \brdrb\brdrs\brdrw10\brsp20 \brdrr\brdrs\brdrw10\brsp80 \aspalpha\aspnum\faauto\adjustright\rin-766\lin0\rtlgutter\itap0 {\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 p\'e5\loch\f1 hjerte og kar \par }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 permissiv for sympatisk vasokonstriksjon \par \hich\af1\dbch\af36\loch\f1 mineralokorticoid virkning gir salt og vann retensjon \par \par }{\f1\fs48\insrsid10887455 \bullet \hich\af1\dbch\af36\loch\f1 }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 hypercortisolisme medf\'f8\loch\f1 rer }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 hypertensjon}{ \f1\fs36\insrsid10887455 \par \par \par }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 p\'e5\loch\f1 muskel \par }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 h\'f8\loch\f1 \hich\f1 y cortisol \'f8\loch\f1 ke\hich\af1\dbch\af36\loch\f1 r proteolysis og hypokalemia \par \par }{\f1\fs48\insrsid10887455 \bullet \hich\af1\dbch\af36\loch\f1 }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 hypercortisolisme medf\'f8\loch\f1 rer }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 muskelsvakhet og svinn}{ \f1\fs36\insrsid10887455 \par \par \par }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 anti-inflammatorisk og immunosuppressiv effekter \par }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 \hich\f1 hemmer fosfolipase A2, et n\'f8\loch\f1 \hich\f1 kkelenzym n\'e5\loch\f1 r det gjelder \par \hich\af1\dbch\af36\loch\f1 \tab syntese av inflammasjonsmediatorene \par \hich\af1\dbch\af36\loch\f1 \tab prostoglandiner, thromboxaner\hich\af1\dbch\af36\loch\f1 , og leukotriener \par \hich\af1\dbch\af36\loch\f1 \hich\f1 hemmer frigj\'f8\loch\f1 ring av proteolytiske enzymer \par \hich\af1\dbch\af36\loch\f1 hemmer leukocytt migrasjon \par \hich\af1\dbch\af36\loch\f1 hemmer neutrofilenes fagocytotisk aktivitet \par \hich\af1\dbch\af36\loch\f1 hemmer fibroblast proliferasjon \par }{\f3\fs36\insrsid10887455 \loch\af3\dbch\af36\hich\f3 \'af\'20}{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 antall eosinofiler, T lymfocytter \par \par }{\f1\fs48\insrsid10887455 \bullet \hich\af1\dbch\af36\loch\f1 }{\f1\fs36\insrsid10887455 \hich\af1\dbch\af36\loch\f1 hypercortisolisme }{\f1\fs36\ul\insrsid10887455 \hich\af1\dbch\af36\loch\f1 demper kroppens immunforsvar}{\f1\fs36\insrsid10887455 \par }\pard \ql \li0\ri-766\widctlpar\aspalpha\aspnum\faauto\adjustright\rin-766\lin0\itap0 {\f1\fs36\insrsid10887455 \par \par \par }}