PENSUM FOR BKJ 4040 -2003
Fra Molecular Biology og the Cell, Fourth Edition (Alberts, B. et al., eds.) 2002, Garland Science, New York and London.
Membrane Structure (kap. 10), side 581-599 (til: cytosolic side of red cells) (19 sider) og side 608-613 (6 sider).
Intracellular compartments and protein sorting (kap. 12), side 659-662 (til: The topological?.) (3sider) side 664 (fra: Proteins can move) -667 (til: most membrane-enclosed organelles) (3 sider) The transport between the nucleus and the cytosol (kap. 12), side 669-674 (til: Transport..) (6 sider). The endoplasmic reticulum (kap. 12), side 689-709 (21 sider)
Intracellular vesicular traffic (kap. 13), 711-766 (56 sider)
How cells read the genome from DNA to protein (kap. 6), The proteasome degrades.., side 358-362 (til: Abnormally folded protein) (4 sider).
Cell communication (kap. 15), The three largest classes of cell-surface receptor..842-848 (til: Cells can respond..) (7 sider) Signalling through G-protein-linked cell-surface receptors, side 852- 865 (some G proteins directly regulate ion channels (13 sider)
The cytoskeleton (kap. 16), side 907-917 (to ?Fimament treadmilling..?(10sider), ?Filament polymerization can be altered by drugs? s.927- (1side), og Extracellular signals side 947-959 (til: motor protein function can be regulated) (13 sider)
Totalt fra l?reboken: 162 sider
Quantitative aspects in the cell
Not such a dismal science: the economics of protein synthesis, folding, degradation aand antigen processing (Yewdell, JW, Trends in cell biol. vol 11 (2001) 294-297) (4 sider).
Membrane composition (including lipids) and fusion/fission
Cholesterol and the Golgi apparatus (M.S.Bretscher and S. Munro, Science vol. 261 (1993) 1280-1281) (2 sider).
Cholesterol, lipid rafts and disease (Kai Simons and Robert Ehehalt, J.Clin.Invest. 110 (2002) 597-603. (6 sider)).
Lipids in endocytic membrane transport and sorting (J. Gruenberg, Curr. Opin. Cell Biol. 15 (2003) 382-388, 5 sider)
Mechanisms of membrane deformation (K. Farsad and P. De Camilli, Curr. Opin. Cell Biol. 15 (2003) 372-381, 7 sider).
Molecular motors
Molecular motors (M. Schliwa and G. Woehlke, Nature, 422(2003) 759-765, 7 sider)
Endocytosis
Regulated portals of entry into the cell (S.D. Conner and S.L. Schmid, Nature 422 (2003) 37-44, 8 sider).
Insider information: What viruses tell us about endocytosis (L. Pelkmans and A. Helenius, Curr. Opin. Cell Biol. 15 (2003) 414-422, 7 sider)
Molecular ticket to enter cells (Oved, S. and Yarden, Y., Nature 416 (2002) 133-136 (4 sider)).
The ubiquitin-dependent endocytosis motif is required for efficient incorporation of growth hormone receptor in clathrin-coated pits, but not clathrin-coated lattices (Sachse, M., et al., J.Cell Sci. 114 (2001) 3943-3952 (10 sider)).
Dynamin at the actin-membrane interface (J.D. Orth and M.A. McNiven, Current Opin. Cell Biol. 15 (2003) 31?39, 7 sider).
Adaptor-related proteins (Robinson and Bonifacino, Curr. Opin. Cell Biol. vol 13 (2001) 444-453 (7 sider)).
Clathrin-mediated endocytosis: membrane factors pull the trigger (Takei, K. and Haucke, V., Trends Cell Biol. vol 11 (2001) 385-391 (6 sider))
Endosomal coat proteins and sorting Annexins (Moss, S.E., Trends Cell Biol., vol. 7 (1997) (3 sider).
Rab proteins as membrane organizers (M. Zerial and H. McBride, Nature Reviews, vol. 2 (2001) 107-117 (11 sider)).
Retrograde traffic in the biosynthetic-secretory route: Pathways and machinery (R. Sannerud, J. Saraste and B. Goud, Curr. Opin. Cell Biol. 15 (2003) 438-445 (6 sider).
Protein sorting into multivesicular endosomes (C. Raiborg, T.E. Rusten and H. Stenmark, Curr. Opin. Cell Biol. 15 (2003) 446-455, 8 sider)
Endoplasmic reticulum og ER-Golgi transport Protein translocation: tunnel vision (Matlack, K.E.S., Mothes, W., and Rapoport, T.A. Cell vol. 92 (1998) 381-390) (10 sider)
Peptide presentation by MHC class I molecules (Williams et al. Trends in Cell Biol. vol. 6 (1996) 267-273) (7 sider).
Quality control in the endoplasmic reticulum (L. Ellgard and A. Helenius, Nature Reviews-Molecular Cell biol., 4 (2003) 181-191, 9 sider)
Signals for COPII-dependent export from the ER: what?s the ticket out? (C. Barlowe, Trends Cell Biol. 13 (2003) 295-300, 5 sider).
Golgi and sorting from the Golgi
The Golgi apparatus: Balancing new with old (B. Storrie and T. Nilsson, Traffic 3 (2002) 521-529 (9 sider)).
Localization of proteins to the Golgi apparatus (S. Munro, Trends Cell Biol., vol. 8 (1998), 11-15) (5 sider).
Golgins in the structure and dynamics of the Golgi apparatus (F.A. Barr and B. Short, Curr. Opin. Cell Biol. 15 (2003) 405-413, 7 sider).
Post-Golgi biosynthetic trafficking (Keller and Simons, J.Cell Sci. vol. 110 (1997) 3001-3009) (9 sider).
Glycans in post-Golgi apical targeting: sorting signals or structural props? (Rodriguez-Boulan and Gonzalez, Trends in Cell Biol. vol 9 (1999)291-294) (4 sider).
The MAL proteolipid is necessary for the overall apical delivery of membrane proteins in the polarized epithelial Madin-Darby canine kidney and Fischer rat thyroid cell lines (Martin-Belmonte, F., Puertollano, R., Millán, J. and Alonso, M.A., Mol. Biol. Cell vol 11 (2000) 2033-2045 (13 sider)).
Protein kinase A A-kinase anchoring proteins: protein kinase A and beyond ( A.S. Edwards and J.D. Scott, Current Opinion Cell Biol. vol 12 (2000) 217-221 (5 sider)).
Toxins Rho proteins:targets for bacterial toxins (Klaus Aktories, Trends in Microbiol. vol. 282 (1997) 282-288).
Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin (K. Sandvig and B.van Deurs, FEBS letters, 26425 (2002) 1-5 (5 sider).
Anbefalt lesing (ikke pensum): Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle (K. Weis, Cell 112 (2003) 441-451) Nuclear localization and possible functions of receptor tyrosine kinases (Graham Carpenter, Curr. Opin. Cell Biol. 15 (2003) 143-148)
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