Olgerta Asko

• Asko, Olgerta; Blenkmann, Alejandro Omar; Leske, Sabine Liliana; Foldal, Maja Dyhre; Anais, Llorens & Funderud, Ingrid [Show all 10 contributors for this article] (2024). Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex. eLIFE. ISSN 2050-084X. 13. doi: 10.7554/eLife.86386.
• Asko, Olgerta; Blenkmann, Alejandro Omar; Leske, Sabine Liliana; Foldal, Maja Dyhre; Anais, Llorens & Funderud, Ingrid [Show all 10 contributors for this article] (2023). Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex. bioRxiv. ISSN 2692-8205. doi: 10.1101/2023.01.04.521570.

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• Blenkmann, Alejandro Omar; Asko, Olgerta; Volehaugen, Vegard; Foldal, Maja Dyhre; Solli, Sandra & Leske, Sabine Liliana [Show all 9 contributors for this article] (2023). Auditory perception, memory, and predictions.
• Asko, Olgerta; Solbakk, Anne-Kristin; Leske, Sabine Liliana; Meling, Torstein Ragnar; Knight, Robert T. & Endestad, Tor [Show all 7 contributors for this article] (2023). The orbitofrontal cortex (OFC) has a critical role in the generation of high-level expectations.
• Asko, Olgerta; Solbakk, Anne-Kristin; Leske, Sabine Liliana; Meling, Torstein Ragnar; Knight, Robert T. & Endestad, Tor [Show all 7 contributors for this article] (2023). Orbitofrontal lesion impacts formation of auditory expectations. Show summary

  Current findings of orbitofrontal cortex (OFC) function suggest that this region might have a role in the generation of prediction error signals associated with top-down expectation of upcoming stimuli. We investigated the impact of lesions to the OFC on the Contingent Negative Variation (CNV), an electrophysiological marker of cognitive expectation and time perception. Twelve OFC patients and fifteen healthy controls performed an auditory local-global paradigm while brain electrical activity was recorded. The structural regularities of the tones were controlled at two hierarchical levels by rules defined at a local (i.e., between tones within sequences) level with a short timescale and at a global (i.e., between sequences) level with a longer timescale. At the global level, deviant tone sequences were interspersed among standard tone sequences in a pseudorandom order, rendering some deviant sequences more anticipated than others. We found that healthy controls exhibited CNV build-up before the occurrence of deviant sequences. The CNV drift rate was modulated by the expectancy of deviant sequences (i.e., the higher the expectancy, the higher the CNV drift rate), reflecting their ability to anticipate when a deviant tone sequence would occur. However, patients with OFC lesions did not show CNV drift modulations by the expectancy of the deviant tone sequences, indicating impaired anticipation of these upcoming events. These findings suggest involvement of the OFC in generating auditory expectations based on the contextual and temporal structure of the task.

• Asko, Olgerta; Blenkmann, Alejandro Omar; Leske, Sabine Liliana; Foldal, Maja Dyhre; Llorens, Ana?s & Funderud, Ingrid [Show all 10 contributors for this article] (2022). Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex. Show summary

  In this study, we tested the causal involvement of the OFC in noticing breaches of predictions (i.e., PEs) at different hierarchical levels of task structural complexity. With this aim, we examined the event-related potentials (ERPs) of patients with focal OFC lesions and healthy adults while performing an auditory local-global oddball paradigm. Altogether, we found that after OFC damage, low-level PEs (i.e., processing of stimuli that are unpredicted at the local level) and combined low- and high-level PEs (i.e., processing of stimuli that are unpredicted at both the local and global level) were impacted. However, the processing of standard tones was not affected. We conclude that the OFC may contribute to a top-down process that modulates the deviance detection system in the primary auditory cortices, and may be involved in connecting PEs at lower hierarchical areas with predictions at higher areas. The study sheds new light on the poorly explored deficits of hierarchical auditory prediction in patients with damaged OFC.

• Stavrinou, Maria; Asko, Olgerta; Hagen, Thomas; Foldal, Maja Dyhre & Espeseth, Thomas (2017). The long term effects of reward on spatial priority maps studied with Electroencephalography and Pupillometry.

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