FYS9720 – Cellular Radiobiology
Course description
Schedule, syllabus and examination date
Course content
The course gives?an overview of the physio-chemical principles of absorption of radiation energy at a molecular and cellular level. Special emphasis is then placed on the effect of radiation on DNA and the principles for repair and misrepair of DNA-damages including the connection with genetic injuries and cancer. Several mathematical models for cell inactivation and its dependency on the dose-rate are included. Central themes are also the variation in radiosensitivity with the cell-cycle stage, radiomodifying factors, and the influence of radiation damage on cell-cycle regulation and cell death (apoptosis/necrosis). The last few lectures give an introduction to the radiobiological principles forming the basis for the mathematical modeling of time-dose relations within radiotherapy including dose-fractionation, calculation of iso-effect curves, and brachytherapy.
Learning outcome
After having completed the course you will:
- be able to describe eukaryotic and prokaryotic cells, and for eukaryotic cells internal and external organization and function, regulation of cell proliferation and growth, some aspects of metabolism and macromolecular synthesis as well as types of DNA damage, chromosomal aberrations, and DNA repair.
- know the mechanistic relation between cell-cycle progression, DNA-repair, and cell survival.
- understand and be able to describe energy deposition by different types of ionizing radiation in solid substances as well as in aqueous solutions. This includes the target theory and concepts like LET and RBE.
- be able to describe the mechanisms for cell inactivation as based on the so-called cellular suicide experiments with incorporated radionuclides.
- understand the tight correlation between cell-cycle regulation and the effect of ionizing radiation in general.
- be able to perform calculations and evaluations based on different models/derivations for cell survival after irradiation.
- understand the role of hypoxia in radiation response and cancer development.
- understand dose rate- and fractionation effects and the underlying biological mechanisms.
- be able to use the alpha-beta-model as a basis for the development of the BED/EQD2-model used for planning of dose-fractionation in radiotherapy.
- understand the importance of biological dose and differential biological responses in particle therapy.
Admission to the course
PhD candidates from the University of Oslo should apply for classes and register for examinations through?Studentweb.
If a course has limited intake capacity, priority will be given to PhD candidates who follow an individual education plan where this particular course is included. Some national researchers’ schools may have specific rules for ranking applicants for courses with limited intake capacity.
PhD candidates who have been admitted to another higher education institution must?apply for a position as a visiting student?within a given deadline.
Formal prerequisite knowledge
The following courses must be passed before the first mandatory laboratory exercise in FYS9720:
Recommended previous knowledge
Overlapping courses
- 10 credits overlap with FYS4720 – Cellular Radio Biology.
Teaching
The course extends?over a whole semester with four hours of lectures per week.
In addition, one week is reserved for the laboratory exercise. The students are divided into groups. The number of hours for laboratory exercise per student (hours by the clock) is approximately 20.
The laboratory exercise is compulsory including a final report. The laboratory report must?be approved before you can take?the final exam. The laboratory report is presented to the sensor during the final oral exam.
As?the?teaching involves laboratory and/or fieldwork, you should consider taking out separate travel and personal risk insurance.?Read about your insurance cover as a student.
Examination
- Final oral or written exam which counts 100 % towards the final grade.
If more than 16 students, the exam will be written.
This course has mandatory exercises that must be approved before you can take the final exam.
It will also be counted as one of the three attempts to sit the exam for this course if you sit the exam for one of the following courses: FYS4720 – Cellular Radio Biology
Examination support material
No examination support material is allowed.
Grading scale
Grades are awarded on a pass/fail scale. Read more about?the grading system.
Resit an examination
Students who can document a valid reason for absence from the regular examination are offered a?postponed exam?at the beginning of the next semester.
New examinations?are offered at the beginning of the next semester for students who do not successfully complete the exam during the previous semester.
We do not offer a re-scheduled exam for students who withdraw during the exam.
More about examinations at UiO
- Use of sources and citations
- Special exam arrangements due to individual needs
- Withdrawal from an exam
- Illness at exams / postponed exams
- Explanation of grades and appeals
- Resitting an exam
- Cheating/attempted cheating
You will find further guides and resources at the web page on examinations at UiO.