Per Morten Sandset

• Wang, He-Ling; Siow, Richard; Schmauck-Medina, Tomas; Zhang, Jianying; Sandset, Per Morten & Filshie, Clare [Show all 38 contributors for this article] (2024). Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies. The journals of gerontology. Series A, Biological sciences and medical sciences. ISSN 1079-5006. 79(4). doi: 10.1093/gerona/glae029.
• Tinholt, Mari; Tekpli, Xavier; Torland, Anne Vold; Tahiri, Andliena; Geisler, J¨¹rgen & Kristensen, Vessela [Show all 8 contributors for this article] (2024). The breast cancer coagulome in the tumor microenvironment and its role in prognosis and treatment response to chemotherapy. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. doi: 10.1016/j.jtha.2024.01.003.
• Shapiro, Amy D.; Nakar, Charles; Parker, Joseph M.; Thibaudeau, Karen; Crea, Roberto & Sandset, Per Morten (2023). Plasminogen, human-tvmh for the treatment of children and adults with plasminogen deficiency type 1. Haemophilia. ISSN 1351-8216. doi: 10.1111/hae.14849. Full text in Research Archive
• Harrison, Sean Philip; Siller, Richard; Tanaka, Yoshiaki; Chollet Dugarte, Maria Eugenia; de la Morena-Barrio, Mar¨ªa Eugenia & Xiang, Yangfei [Show all 36 contributors for this article] (2023). Scalable production of tissue-like vascularized liver organoids from human PSCs. Experimental and Molecular Medicine. ISSN 1226-3613. 55, p. 2005¨C2024. doi: 10.1038/s12276-023-01074-1. Full text in Research Archive
• Larsen, Trine-Lise; Svalastoga, Marte; Brekke, Jorunn; Enden, Tone R?nnaug; Fr?en, Hege & Garresori, Herish [Show all 16 contributors for this article] (2023). Arterial events in cancer patients treated with apixaban for venous thrombosis. Thrombosis Research. ISSN 0049-3848. 228, p. 128¨C133. doi: 10.1016/j.thromres.2023.05.017.
• Pradier, Michelle; Rodger, Marc A.; Ghanima, Waleed; Kovacs, Michael J.; Shivakumar, Sudeep & Kahn, Susan R. [Show all 10 contributors for this article] (2023). Performance and Head-to-Head Comparison of Three Clinical Models to Predict Occurrence of Postthrombotic Syndrome: A Validation Study. Thrombosis and Haemostasis. ISSN 0340-6245. 123(7), p. 692¨C699. doi: 10.1055/a-2039-3388.
• Roman, Giacomo; Stavik, Benedicte; Lauritzen, Knut Hus?; Sandset, Per Morten; Harrison, Sean & Sullivan, Gareth John [Show all 7 contributors for this article] (2023). ¡°iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives¡±. Frontiers in Physiology. ISSN 1664-042X. 14. doi: 10.3389/fphys.2023.1094249. Full text in Research Archive
• Garabet, Lamya Samir Noori; Eriksson, Anna Maria; Tj?nnfjord, Eirik; Cui, Xueyan; Olsen, Magnus Kringstad & Jacobsen, Hege [Show all 18 contributors for this article] (2022). SARS-CoV-2 vaccines are not associated with hypercoagulability in apparently healthy people. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 7(1). doi: 10.1016/j.rpth.2022.100002. Full text in Research Archive
• Cui, Xueyan; Stavik, Benedicte; Thiede, Bernd; Sandset, Per Morten & Kanse, Sandip (2022). FSAP Protects against Histone-Mediated Increase in Endothelial Permeability In Vitro. International Journal of Molecular Sciences. ISSN 1661-6596. 23(22). doi: 10.3390/ijms232213706. Full text in Research Archive
• Etscheid, Michael; Hanschmann, Kay Martin; Sandset, Per Morten & Kanse, Sandip (2022). Development of a Factor VII Activating Protease (FSAP) generation assay and its application in studying FSAP in venous thrombosis. Thrombosis Research. ISSN 0049-3848. 220, p. 24¨C34. doi: 10.1016/j.thromres.2022.09.027. Full text in Research Archive
• Ng, Sara; Rodger, Marc A.; Ghanima, Waleed; Kovacs, Michael J.; Shivakumar, Sudeep & Kahn, Susan R. [Show all 10 contributors for this article] (2022). External Validation of the Patient-Reported Villalta Scale for the Diagnosis of Postthrombotic Syndrome. Thrombosis and Haemostasis. ISSN 0340-6245. 122(8), p. 1379¨C1383. doi: 10.1055/a-1738-1313.
• de la Morena-Barrio, Maria Eugenia; Suchon, Pierre; Jacobsen, Eva-Marie; Iversen, Nina; Mi?ano, Antonia & de la Morena-Barrio, Bel¨¦n [Show all 17 contributors for this article] (2022). Two SERPINC1 variants affecting N-glycosylation of Asn224 cause severe thrombophilia not detected by functional assays. Blood. ISSN 0006-4971. 140(2), p. 140¨C151. doi: 10.1182/blood.2021014708. Show summary

  Antithrombin deficiency, the most severe congenital thrombophilia, might be underestimated, as some pathogenic variants are not detected by routine functional methods. We have identified 2 new SERPINC1 variants, p.Glu227Lys and p.Asn224His, in 4 unrelated thrombophilic patients with early and recurrent thrombosis that had normal antithrombin activity. In one case, the mutation was identified by whole genome sequencing, while in the 3 remaining cases, the mutation was identified by sequencing SERPINC1 based on a single functional positive finding supporting deficiency. The 2 variants shared a common functional defect, an impaired or null N-glycosylation of Asn224 according to a eukaryotic expression model. Carriers had normal anti-FXa or anti-FIIa activities but impaired anti-FVIIa activity and a detectable loss of inhibitory function when incubating the plasma for 1 hour at 41¡ãC. Moreover, the b glycoform of the variants, lacking 2 N-glycans, had reduced secretion, increased heparin affinity, no inhibitory activity, and a potential dominant¨Cnegative effect. These results explain the increased thrombin generation observed in carriers. Mutation experiments reflected the role that Lysine residues close to the N-glycosylation sequon have in impairing the efficacy of N-glycosylation. Our study shows new elements involved in the regulation of N-glycosylation, a key posttranslational modification that, according to our results, affects folding, secretion, and function, providing new evidence of the pathogenic consequence of an incorrect N-glycosylation of antithrombin. This study supports that antithrombin deficiency is underestimated and encourages the development of new functional and genetic tests to diagnose this severe thrombophilia.

• Larsen, Trine-Lise; Garresori, Herish; Brekke, Jorunn; Enden, Tone R?nnaug; Fr?en, Hege & Jacobsen, Eva-Marie [Show all 15 contributors for this article] (2022). Low dose apixaban as secondary prophylaxis of venous thromboembolism in cancer patients ¨C 30 months follow-up. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 20(5), p. 1166¨C1181. doi: 10.1111/jth.15666. Full text in Research Archive Show summary

  Background There are no data on the effect of low-dose anticoagulation as secondary prophylaxis for venous thromboembolism (VTE) in cancer patients. We assessed the efficacy and safety of low-dose apixaban for 30 months, after initial 6 months of full-dose treatment. Methods We included 298 patients with cancer and any type of VTE in a single arm interventional clinical trial. All patients were treated with full-dose apixaban (5 mg twice daily) for 6 months. Total 196 patients with active cancer after 6 months treatment continued with apixaban 2.5 mg twice daily for another 30 months. The main endpoints were recurrent VTE, major bleeding and clinically relevant non-major bleeding. Results During the 30 months of treatment with low-dose apixaban 14 (7.6%; 95% confidence interval (CI) 4.0%¨C11.7%) patients experienced recurrent VTE, six (3.1%; 95% CI 1.1%¨C6.5%) experienced major bleeding and 16 (8.1%, 95% CI: 4.7%¨C12.8%) experienced clinically relevant non-major bleeding. The incidence rate per person month of recurrent VTE was 0.8% (95% CI 0.41¨C1.6) at 2¨C6 months with full-dose apixaban, and 1.0% (95% CI 0.5¨C1.9) at 7¨C12 months with low-dose apixaban. The incidence rate of major bleeding was 1.1% (95% CI 0.6¨C2.0) at 2¨C6 months, and 0.3% (95% CI 0.1¨C1.0) at 7¨C12 months. Between 12 and 36 months the incidence rate of recurrent VTE and major bleedings remained low. Conclusion Dose reduction of apixaban to 2.5 mg twice daily seems safe after 6 months of full-dose treatment. After 12 months the incidence rate of recurrent VTE and major bleeding remained low.

• Delluc, Aur¨¦lien; Ghanima, Waleed; Kovacs, Michael J.; Shivakumar, Sudeep; Kahn, Susan R. & Sandset, Per Morten [Show all 9 contributors for this article] (2022). Prevention of post-thrombotic syndrome with rosuvastatin: A multicenter randomized controlled pilot trial (SAVER). Thrombosis Research. ISSN 0049-3848. 213, p. 119¨C124. doi: 10.1016/j.thromres.2022.03.014.
• Skaga, Nils Oddvar; Holtan, Anders; Inger, Haug & Sandset, Per Morten (2022). KOAGULASJONSBOKS P? TRAUMESTUA I AKUTTMOTTAKET OSLO UNIVERSITETSSYKEHUS ¨C ULLEV?L (Versjon VI, 16.02.2022). Kirurgen. ISSN 1504-8888. p. 21¨C25.
• Skaga, Nils Oddvar; Holtan, Anders; Haug, Inger & Sandset, Per Morten (2022). MEDIKAMENTBRUK VED KRITISK BL?DNING OG REVERSERING AV ANTITROMBOTISKE LEGEMIDLER ¨C PROTOKOLL I TRAUMEMOTTAKET VED OUS ULLEV?L. Kirurgen. ISSN 1504-8888. p. 20¨C21.
• Martin, Karlyn A.; Beyer-Westendorf, Jan; Davidson, Bruce L.; Huisman, Menno V.; Sandset, Per Morten & Moll, S. (2021). Use of direct oral anticoagulants in patients with obesity for treatment and prevention of venous thromboembolism: Updated communication from the ISTH SSC Subcommittee on Control of Anticoagulation. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 19(8), p. 1874¨C1882. doi: 10.1111/jth.15358.
• Andersen, Elisabeth; Dugarte, Maria Eugenia Chollet; Bernardi, Francesco; Branchini, Alessio; Baroni, Marcello & Mariani, Guglielmo [Show all 12 contributors for this article] (2021). The factor vii variant p.A354v-p.p464hfs: Clinical versus intracellular and biochemical phenotypes induced by chemical chaperones. Applied Sciences. ISSN 2076-3417. 11(13). doi: 10.3390/app11135762. Full text in Research Archive
• Andresen, Marianne Seierstad; Sletten, Marit; Sandset, Per Morten; Iversen, Nina; Stavik, Benedicte & Tinholt, Mari (2021). Coagulation Factor v (F5) is an Estrogen-Responsive Gene in Breast Cancer Cells. Thrombosis and Haemostasis. ISSN 0340-6245. 122(8), p. 1288¨C1295. doi: 10.1055/a-1707-2130.
• Delluc, Aur¨¦lien; Ghanima, Waleed; Kovacs, Michael J.; Shivakumar, Sudeep; Kahn, Susan R. & Sandset, Per Morten [Show all 9 contributors for this article] (2021). Statins for venous event reduction in patients with venous thromboembolism: A multicenter randomized controlled pilot trial assessing feasibility. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 20(1), p. 126¨C132. doi: 10.1111/jth.15537.
• Ihle-Hansen, H?kon; Hagberg, Guri; Sandset, Else Charlotte; Ihle-Hansen, Hege; Amundsen, Erik Koldberg & Sandset, Per Morten [Show all 7 contributors for this article] (2021). Reversering av antikoagulerende legemidler ved hjernebl?dning. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(14), p. 1¨C6. doi: 10.4045/tidsskr.21.0063. Full text in Research Archive
• Wik, Hilde Skuterud; Kahn, Susan; Eriksson, Henry; Morrison, David; Ghanima, Waleed & Schulman, Sam [Show all 7 contributors for this article] (2021). Post-thrombotic syndrome in patients with venous thromboembolism treated with dabigatran or warfarin: A long-term cross-sectional follow-up of RE-COVER study patients. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. p. 1¨C9. doi: 10.1111/jth.15449. Full text in Research Archive
• Jacobsen, Anne Flem & Sandset, Per Morten (2021). Prior Thromboembolic Disease and Assisted Reproductive Therapy. Seminars in Reproductive Medicine. ISSN 1526-8004. doi: 10.1055/s-0041-1732375. Full text in Research Archive
• Cui, Xueyan; Tj?nnfjord, Geir Erland; Kanse, Sandip; Dahm, Anders Erik A; Iversen, Nina & Myklebust, Christiane Filion [Show all 12 contributors for this article] (2021). Tissue factor pathway inhibitor upregulates CXCR7 expression and enhances CXCL12-mediated migration in chronic lymphocytic leukemia. Scientific Reports. ISSN 2045-2322. 11. doi: 10.1038/s41598-021-84695-8. Full text in Research Archive
• Khialani, Deeksha; Vasan, Sowmya; Cushman, Mary; Dahm, Anders Erik A; Sandset, Per Morten & Rossouw, Jacques [Show all 7 contributors for this article] (2021). Venous thrombosis with oral postmenopausal hormone therapy: Roles of activated protein C resistance and tissue factor pathway inhibitor. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 19(7), p. 1729¨C1737. doi: 10.1111/jth.15319.
• Engeseth, Marit; Enden, Tone R?nnaug; Sandset, Per Morten & Wik, Hilde Skuterud (2021). Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study. Thrombosis Journal. ISSN 1477-9560. 19:3, p. 1¨C7. doi: 10.1186/s12959-020-00253-8. Full text in Research Archive
• B?hn, Siv Kj?lsrud; Thune, Inger; Flote, Vidar Gordon; Frydenberg, Hanne; Bertheussen, Gro Falkener & Hus?y, Anders [Show all 12 contributors for this article] (2021). Effects of a One-Year Physical Activity Intervention on Markers of Hemostasis among Breast Cancer Survivors - A Randomized Controlled Trial. TH Open. ISSN 2512-9465. 5(1), p. e14¨Ce23. doi: 10.1055/s-0040-1721782. Full text in Research Archive Show summary

  Introduction?Physical activity may reduce the development of breast cancer. Whereas hypercoagulability has been linked to adverse outcomes in breast cancer patients, the effects of physical activity on their hemostatic factors are unknown. The study aimed to assess whether long-term (1 year) physical activity can affect hemostatic factors in breast cancer patients. Methods?Fifty-five women (35¨C75 years) with invasive breast cancer stage I/II were randomized to a physical activity intervention (n?=?29) lasting 1 year or to a control group (n?=?26), and analyzed as intention to treat. Fibrinogen, factor VII antigen, tissue factor pathway inhibitor, and von Willebrand factor (VWF) antigen as well as prothrombin fragment 1?+?2, the endogenous thrombin potential and D-dimer, were measured in plasma before intervention (baseline), and then after 6 and 12 months. Results?Maximal oxygen uptake (measure of cardiorespiratory fitness) decreased the first 6 months among the controls, but remained stable in the intervention group. We found no significant differences between the two study groups regarding any of the hemostatic factors, except a significantly higher increase in factor VII antigen in the intervention group. The effect of the intervention on VWF was, however, significantly affected by menopausal stage, and a significant effect of the intervention was found on VWF among postmenopausal women, even after adjustment for dietary intake. Conclusion?Long-term physical activity had no effect on the majority of the hemostatic factors measured, but led to increased plasma concentrations of factor VII antigen and prevented an increase in VWF concentration after breast cancer treatment in postmenopausal women. The clinical impact of these findings for risk of vascular thrombosis warrants further studies.

• Tritschler, Tobias; Sandset, Per Morten; Mathieu, Marie-Eve; Skeith, Leslie; Rodger, Marc & Middeldorp, Saskia [Show all 34 contributors for this article] (2020). Anticoagulant interventions in hospitalized patients with COVID-19: A scoping review of randomized controlled trials and call for international collaboration. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. doi: 10.1111/jth.15094.
• Harrison, Sean; Siller, Richard; Tanaka, Yoshiaki; Xiang, Yangfei; Patterson, Benjamin & Kempf, Henning [Show all 29 contributors for this article] (2020). Scalable production of tissue-like vascularised liver organoids from human PSCs. bioRxiv. ISSN 2692-8205. doi: 10.1101/2020.12.02.406835.
• Andresen, Marianne Seierstad; Stavik, Benedicte; Sletten, Marit; Tinholt, Mari; Sandset, Per Morten & Iversen, Nina [Show all 7 contributors for this article] (2020). Indirect regulation of TFPI-2 expression by miR-494 in breast cancer cells . Scientific Reports. ISSN 2045-2322. 10:4036, p. 1¨C10. doi: 10.1038/s41598-020-61018-x. Full text in Research Archive
• Godolphin, Peter J.; Bath, Philip M.; Partlett, Christopher; Berge, Eivind; Brown, Martin M & Eliasziw, Misha [Show all 9 contributors for this article] (2020). Outcome assessment by central adjudicators in randomised stroke trials: Simulation of differential and non-differential misclassification. European Stroke Journal. ISSN 2396-9873. 5(2), p. 174¨C183. doi: 10.1177/2396987320910047. Full text in Research Archive
• Andersen, Nina Gjerde; Mowinckel, Marie-Christine; Sunde, Kjetil; Sandset, Per Morten & Beitland, Sigrid (2020). Utility of coagulation analyses to assess thromboprophylaxis with dalteparin in intensive care unit patients. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. p. 1¨C10. doi: 10.1111/aas.13748. Full text in Research Archive
• Hannevik, Trine-Lise; Brekke, Jorunn; Enden, Tone R?nnaug; Fr?en, Hege; Ahmed, Herish & Jacobsen, Eva-Marie [Show all 15 contributors for this article] (2020). Thrombosis and bleedings in a cohort of cancer patients treated with apixaban for venous thromboembolism. Thrombosis Research. ISSN 0049-3848. 196, p. 238¨C244. doi: 10.1016/j.thromres.2020.08.042.
• Thorsen, Lene; Haugnes, Hege Sagstuen; Foss?, Sophie Dorothea; Bryd?y, Marianne; Tandstad, Torgrim & Wisl?ff, Torbj?rn [Show all 13 contributors for this article] (2020). Thromboembolic events after high-intensity training duringcisplatin-based chemotherapy for testicular cancer: Casereports and review of the literature. International Journal of Cancer. ISSN 0020-7136. 147(11), p. 3189¨C3198. doi: 10.1002/ijc.33151. Full text in Research Archive Show summary

  The randomized ¡°Testicular cancer and Aerobic and Strength Training trial¡± (TAST©\trial) aimed to evaluate the effect of high©\intensity interval training (HIIT) on cardiorespiratory fitness during cisplatin©\based chemotherapy (CBCT) for testicular cancer (TC). Here, we report on an unexpected high number of thromboembolic (TE) events among patients randomized to the intervention arm, and on a review of the literature on TE events in TC patients undergoing CBCT. Patients aged 18 to 60?years with a diagnosis of metastatic germ cell TC, planned for 3 to 4 CBCT cycles, were randomized to a 9 to 12?weeks exercise intervention, or to a single lifestyle counseling session. The exercise intervention included two weekly HIIT sessions, each with 2 to 4 intervals of 2 to 4 minutes at 85% to 95% of peak heart rate. The study was prematurely discontinued after inclusion of 19 of the planned 94 patients, with nine patients randomized to the intervention arm and 10 to the control arm. Three patients in the intervention arm developed TE complications; two with pulmonary embolism and one with myocardial infarction. All three patients had clinical stage IIA TC. No TE complications were observed among patients in the control arm. Our observations indicate that high©\intensity aerobic training during CBCT might increase the risk of TE events in TC patients, leading to premature closure of the TAST©\trial.

• Tinholt, Mari; Stavik, Benedicte; Tekpli, Xavier; Garred, ?ystein; Borgen, Elin & Kristensen, Vessela N. [Show all 9 contributors for this article] (2020). Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer. Oncoimmunology. ISSN 2162-4011. 9:e1824644(1), p. 1¨C12. doi: 10.1080/2162402X.2020.1824644. Full text in Research Archive
• Garabet, Lamya Samir Noori; Henriksson, Carola; Lozano, Maria Luisa; Ghanima, Waleed Khalid; Bussel, James & Brodin, Ellen Elisabeth [Show all 11 contributors for this article] (2019). Markers of endothelial cell activation and neutrophil extracellular traps are elevated in immune thrombocytopenia but are not enhanced by thrombopoietin reseptor agonists. Thrombosis Research. ISSN 0049-3848. 185, p. 119¨C124. doi: 10.1016/j.thromres.2019.11.031. Full text in Research Archive
• Gregersen, Ida; H?ibraaten, Else; Holven, Kirsten Bj?rklund; L?vdahl, Lene; Ueland, Thor & Mowinckel, Marie-Christine [Show all 10 contributors for this article] (2019). Effect of hormone replacement therapy on atherogenic lipid profile in postmenopausal women. Thrombosis Research. ISSN 0049-3848. 184, p. 1¨C7. doi: 10.1016/j.thromres.2019.10.005. Full text in Research Archive
• Engeseth, Marit; Enden, Tone R?nnaug; Sandset, Per Morten & Wik, Hilde Skuterud (2019). Limitations of the Villalta scale in diagnosing post-thrombotic syndrome. Thrombosis Research. ISSN 0049-3848. 184, p. 62¨C66. doi: 10.1016/j.thromres.2019.10.018. Full text in Research Archive
• Andersen, Elisabeth; Dugarte, Maria Eugenia Chollet; Baroni, Marcello; Pinotti, Mirko; Bernardi, Francesco & Skarpen, Ellen [Show all 8 contributors for this article] (2019). The effect of the chemical chaperone 4-phenylbutyrate on secretion and activity of the p.Q160R missense variant of coagulation factor FVII. Cell & Bioscience. ISSN 2045-3701. 9:69, p. 1¨C10. doi: 10.1186/s13578-019-0333-8. Full text in Research Archive
• Dahm, Anders Erik A; Jacobsen, Eva-Marie; Wik, Hilde Skuterud; Jacobsen, Anne Flem; Mollnes, Tom Eirik & Kanse, Sandip [Show all 7 contributors for this article] (2019). Elevated complement C3 and C4 levels are associated with postnatal pregnancy-related venous thrombosis. Thrombosis and Haemostasis. ISSN 0340-6245. 119(9), p. 1481¨C1488. doi: 10.1055/s-0039-1692426. Full text in Research Archive
• Engeseth, Marit; Enden, Tone R?nnaug; Andersen, Marit Helen; Sandset, Per Morten & Wik, Hilde Skuterud (2019). Does the Villalta scale capture the essence of postthrombotic syndrome? A qualitative study of patient experience and expert opinion. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. p. 1¨C8. doi: 10.1111/jth.14557. Full text in Research Archive
• Garabet, Lamya Samir Noori; Ghanima, Waleed Khalid; Hellum, Marit Synn?ve; Sandset, Per Morten; Bussel, James B. & Tran, Hoa Thi Tuyet [Show all 7 contributors for this article] (2019). Increased microvesicle-associated thrombin generation in patients with immune thrombocytopenia after initiation of thrombopoietin receptor agonists. Platelets. ISSN 0953-7104. doi: 10.1080/09537104.2019.1639655.
• Garabet, Lamya Samir Noori; Ghanima, Waleed Khalid; Rangberg, Anbj?rg; Teruel-Montoya, Raul; Martinez, Constantino & Lozano, Maria Luisa [Show all 10 contributors for this article] (2019). Circulating microRNAs in patients with immune thrombocytopenia before and after treatment wirh thrombopoietin-receptor agonists. Platelets. ISSN 0953-7104. p. 1¨C8. doi: 10.1080/09537104.2019.1585527. Full text in Research Archive
• Godolphin, Peter J.; Bath, Philip M.; Algra, Ale; Berge, Eivind; Brown, Christopher Martin & Chalmers, John [Show all 19 contributors for this article] (2019). Outcome assessment by central adjudicators versus site investigators in stroke trials: A systematic review and meta-analysis. Stroke. ISSN 0039-2499. 50(8), p. 2187¨C2196. doi: 10.1161/STROKEAHA.119.025019. Full text in Research Archive Show summary

  Background and Purpose¡ª In randomized stroke trials, central adjudication of a trial¡¯s primary outcome is regularly implemented. However, recent evidence questions the importance of central adjudication in randomized trials. The aim of this review was to compare outcomes assessed by central adjudicators with outcomes assessed by site investigators. Methods¡ª We included randomized stroke trials where the primary outcome had undergone an assessment by site investigators and central adjudicators. We searched MEDLINE, EMBASE, CENTRAL (Cochrane Central Register of Controlled Trials), Web of Science, PsycINFO, and Google Scholar for eligible studies. We extracted information about the adjudication process as well as the treatment effect for the primary outcome, assessed both by central adjudicators and by site investigators. We calculated the ratio of these treatment effects so that a ratio of these treatment effects >1 indicated that central adjudication resulted in a more beneficial treatment effect than assessment by the site investigator. A random-effects meta-analysis model was fitted to estimate a pooled effect. Results¡ª Fifteen trials, comprising 69?560 participants, were included. The primary outcomes included were stroke (8/15, 53%), a composite event including stroke (6/15, 40%) and functional outcome after stroke measured on the modified Rankin Scale (1/15, 7%). The majority of site investigators were blind to treatment allocation (9/15, 60%). On average, there was no difference in treatment effect estimates based on data from central adjudicators and site investigators (pooled ratio of these treatment effects=1.02; 95% CI, [0.95¨C1.09]). Conclusions¡ª We found no evidence that central adjudication of the primary outcome in stroke trials had any impact on trial conclusions. This suggests that potential advantages of central adjudication may not outweigh cost and time disadvantages in stroke studies if the primary purpose of adjudication is to ensure validity of trial findings.

• Skretting, Grethe; Andersen, Elisabeth; Myklebust, Christiane Filion; Sandset, Per Morten; Tinholt, Mari & Iversen, Nina [Show all 7 contributors for this article] (2019). Transcription factor FOXP3: A repressor of the TFPI gene? Journal of Cellular Biochemistry. ISSN 0730-2312. p. 1¨C13. doi: 10.1002/jcb.28563.
• Eilertsen, Anette L?ken; Dahm, Anders Erik A; H?ibraaten, Else; Lofthus, Cathrine Marie; Mowinckel, Marie-Christine & Sandset, Per Morten (2019). Relationship between sex hormone binding globulin and blood coagulation in women on postmenopausal hormone treatment. Blood Coagulation and Fibrinolysis. ISSN 0957-5235. 30(1), p. 17¨C23. doi: 10.1097/MBC.0000000000000784.
• Beitland, Sigrid; Wimmer, Rolf Henning; Lorentsen, Torleif; Jacobsen, Dag; Dr?gni, Tomas & Brunborg, Cathrine [Show all 9 contributors for this article] (2019). Venous thromboembolism in the critically ill: A prospective observational study of occurrence, risk factors and outcome. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 63(5), p. 630¨C638. doi: 10.1111/aas.13316. Full text in Research Archive
• Garabet, Lamya Samir Noori; Ghanima, Waleed Khalid; Jonassen, Christine Monceyron; Skov, Vibe; Holst, Ren¨¦ & Mowinckel, Marie-Christine [Show all 12 contributors for this article] (2019). Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia. Platelets. ISSN 0953-7104. 30(2), p. 206¨C212. doi: 10.1080/09537104.2017.1394451.
• Schultz, Nina Haagenrud; Holme, P?l Andre; Bj?rnsen, Stine; Henriksson, Carola; Sandset, Per Morten & Jacobsen, Eva-Marie (2018). The impact of rivaroxaban on primary hemostasis in patients with venous thrombosis. Platelets. ISSN 0953-7104. doi: 10.1080/09537104.2018.1557618.
• Tavoly, Mazdak; Wik, Hilde Skuterud; Sirnes, Per-Anton; Jelsness-J?rgensen, Lars-Petter; Ghanima, Josef P. & Klok, Frederikus A. [Show all 8 contributors for this article] (2018). The impact of post-pulmonary embolism syndrome and its possible determinants. Thrombosis Research. ISSN 0049-3848. 171, p. 84¨C91. doi: 10.1016/j.thromres.2018.09.048.
• Sacco, Simona; Merki-Feld, Gabriele S.; ?gidius, Karen Lehrmann; Bitzer, Johannes; Canonico, Marianne & Gantenbein, Andreas R. [Show all 19 contributors for this article] (2018). Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: A consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH). The Journal of Headache and Pain. ISSN 1129-2369. 19(76). doi: 10.1186/s10194-018-0896-5. Full text in Research Archive
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• Gravensteen, Ida Kathrine; Jacobsen, Eva-Marie; Sandset, Per Morten; Helgad¨®ttir, Linda Bj?rk; R?destad, Ingela & Sandvik, Leiv [Show all 7 contributors for this article] (2018). Anxiety, depression and relationship satisfaction in the pregnancy following stillbirth and after the birth of a live-born baby: A prospective study. BMC Pregnancy and Childbirth. ISSN 1471-2393. 18(41). doi: 10.1186/s12884-018-1666-8. Full text in Research Archive
• Andersen, Elisabeth; Dugarte, Maria Eugenia Chollet; Myklebust, Christiane Filion; Pinotti, Mirko; Bernardi, Francesco & Chuansumrit, Ampaiwan [Show all 9 contributors for this article] (2018). Activation of Endoplasmic Reticulum Stress and Unfolded Protein Response in Congenital Factor VII Deficiency. Thrombosis and Haemostasis. ISSN 0340-6245. 118(4), p. 664¨C675. doi: 10.1055/s-0038-1637690.
• Kostovski, Emil; Frigato, E; Savikj, Mladen; Dahm, Anders Erik A; Sandset, Per Morten & Mowinckel, Marie-Christine [Show all 10 contributors for this article] (2018). Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation. Spinal Cord. ISSN 1362-4393. p. 1¨C8. doi: 10.1038/s41393-018-0176-x. Full text in Research Archive
• Wik, Hilde Skuterud; Enden, Tone R?nnaug; Ghanima, Waleed Khalid; Engeseth, Marit; Kahn, Susan R. & Sandset, Per Morten (2018). Diagnostic scales for the post-thrombotic syndrome. Thrombosis Research. ISSN 0049-3848. 164, p. 110¨C115. doi: 10.1016/j.thromres.2017.10.022.
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• Shapiro, Amy D.; Nakar, Charles; Parker, Joseph M.; Albert, Gary R.; Moran, John E. & Thibaudeau, Karen [Show all 10 contributors for this article] (2018). Plasminogen replacement therapy for the treatment of children and adults with congenital plasminogen deficiency. Blood. ISSN 0006-4971. 131(12), p. 1301¨C1310. doi: 10.1182/blood-2017-09-806729.
• Tikkinen, Kari A.O.; Craigie, Samantha; Agarwal, Arnav; Violette, Philippe D.; Novara, Giacomo & Cartwright, Rufus [Show all 16 contributors for this article] (2018). Procedure-specific risks of thrombosis and bleeding in urological cancer surgery: systematic review and meta-analysis. European Urology. ISSN 0302-2838. 73(2), p. 242¨C251. doi: 10.1016/j.eururo.2017.03.008. Full text in Research Archive
• Utne, Kristin Kornelia; Dahm, Anders Erik A; Wik, Hilde Skuterud; Jelsness-J?rgensen, Lars-Petter; Sandset, Per Morten & Ghanima, Waleed Khalid (2018). Rivaroxaban versus warfarin for the prevention of post-thrombotic syndrome. Thrombosis Research. ISSN 0049-3848. 163, p. 6¨C11. doi: 10.1016/j.thromres.2018.01.013.
• Gravensteen, Ida Kathrine; Jacobsen, Eva-Marie; Sandset, Per Morten; Helgad¨®ttir, Linda Bj?rk; R?destad, Ingela & Sandvik, Leiv [Show all 7 contributors for this article] (2018). Healthcare utilisation, induced labour and caesarean section in the pregnancy after stillbirth: a prospective study. BJOG: An International Journal of Obstetrics and Gynaecology. ISSN 1470-0328. 125(2), p. 202¨C210. doi: 10.1111/1471-0528.14750. Full text in Research Archive
• Amundsen, Erik Koldberg; Skadberg, ?yvind; Ghanima, Waleed Khalid; Fr?n?s, Synne Gr?nvold; Dahm, Anders Erik A & T?sdal, Margunn Bye [Show all 9 contributors for this article] (2018). D-Dimer: Aldersjusterte beslutningsgrenser ved diagnostikk av ven?s tromboembolisme? Klinisk Biokemi i Norden. ISSN 1101-2013. 30(1), p. 26¨C36.
• Dugarte, Maria Eugenia Chollet; Andersen, Elisabeth; Skarpen, Ellen; Myklebust, Christiane Filion; Koehler, Christian & Morth, Jens Preben [Show all 12 contributors for this article] (2018). Factor VII deficiency: Unveiling the cellular and molecular mechanisms underlying Three model alterations of the enzyme catalytic domain. Biochimica et Biophysica Acta - Molecular Basis of Disease. ISSN 0925-4439. 1864(3), p. 660¨C667. doi: 10.1016/j.bbadis.2017.12.016.
• Schultz, Nina Haagenrud; Tran, Hoa Thi Tuyet; Bj?rnsen, Stine; Henriksson, Carola Elisabeth; Sandset, Per Morten & Holme, P?l Andre (2017). The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII in apixaban-treated patients in vitro. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 1(1), p. 49¨C56. doi: 10.1002/rth2.12015.
• Tikkinen, Kari A. O.; Craigie, Samantha; Agarwal, Arnav; Siemieniuk, Reed A.C.; Cartwright, Rufus & Violette, Philippe D. [Show all 16 contributors for this article] (2017). Procedure-specific Risks of Thrombosis and Bleeding in Urological Non-cancer Surgery: Systematic Review and Meta-analysis. European Urology. ISSN 0302-2838. 73(2), p. 236¨C241. doi: 10.1016/j.eururo.2017.02.025.
• Sagedal, Solbj?rg; Sandvik, Leiv; Klingenberg, Olav & Sandset, Per Morten (2017). ¦Â-Thromboglobulin may not reflect platelet activation during haemodialysis with the HeprAN membrane. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 77(8), p. 679¨C684. doi: 10.1080/00365513.2017.1397288.
• Sacco, Simona; Merki-Feld, Gabriele S.; ?gidius, Karen Lehrmann; Bitzer, Johannes; Canonico, Marianne & Kurth, Tobias [Show all 15 contributors for this article] (2017). Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC). The Journal of Headache and Pain. ISSN 1129-2369. 18:108, p. 1¨C20. doi: 10.1186/s10194-017-0815-1.
• Cui, Xue-Yan; Skretting, Grethe; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A & Sahlberg, Kristine Kleivi [Show all 9 contributors for this article] (2017). A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7. Thrombosis Research. ISSN 0049-3848. 157, p. 111¨C116. doi: 10.1016/j.thromres.2017.07.013.

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• Barrabes, Veronika; Fredriksen, Magne Wang; Ron?s, Johan; Getz, Linn Okkenhaug; Sandset, Per Morten & Tangen, Marte Kvittum (2023). Fremtidens helsetjenester - kollaps eller suksess? Kommunal rapport. ISSN 0801-6410.
• Chollet Dugarte, Maria Eugenia; Andersen, Elisabeth; Harrison, Sean Philip; de la Morena-Barrio, Maria Eugenia; Baumgarten, Saphira Felicitas & Bhattacharya, Anindita [Show all 14 contributors for this article] (2023). OC 07.5 Modeling and Correcting FVII Deficiency using Human Stem Cell-Derived Hepatic Organoids. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 7(Oral communications ISTH 2023). doi: 10.1016/j.rpth.2023.100470.
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• Lauritzen, Knut Hus?; Sullivan, Gareth John; Harrison, Sean Philip; Iversen, Nina; Henriksson, Carola Elisabeth & Glosli, Heidi [Show all 9 contributors for this article] (2023). OC 07.1 Autologous CRISPR/Cas9 Correction of a Missense Variant from a Patient with Severe, Inherited FVII Deficiency. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. doi: 10.1016/j.rpth.2023.100475.
• Larsen, Trine-Lise; Ghanima, Waleed; Sandset, Per Morten; Fr?en, Hege; Jacobsen, Eva-Marie & Torfoss, Dag [Show all 7 contributors for this article] (2023). Faktor Xa-hemmere til forebygging og behandling av ven?s tromboembolisme ved kreft. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(1). doi: 10.4045/tidsskr.22.0228. Full text in Research Archive
• Cui, Xueyan; Myklebust, June Helen; Munthe, Ludvig A; Schjesvold, Fredrik Hellem; Tj?nnfjord, Geir Erland & Stavik, Benedicte [Show all 7 contributors for this article] (2022). Single-cell sequencing reveals procoagulant microenvironment in precursor stages of multiple myeloma .
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• Cui, Xueyan; Stavik, Benedicte; Sandset, Per Morten & Kanse, Sandip (2022). The role of FSAP in regulating endothelial permeability. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379.
• Andresen, Marianne Seierstad; Mowinckel, Marie-Christine; Stavik, Benedicte; Sandset, Per Morten & Dugarte, Maria Eugenia Chollet (2022). Evaluation of Pharmacological Enhancers of Mutated Factor VII Activity ex vivo. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379.
• Hernes, Toril A. Nagelhus; Sandset, Per Morten; Greve, Gottfried; Brekke, Camilla; Fitjar, Rune Dahl & Hann?s, G?ril (2022). Vi har ikke tid til at finansiering av forskning settes p? vent. Khrono.no. ISSN 1894-8995.
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• Dahm, Anders Erik A & Sandset, Per Morten (2021). Tissue factor pathway inhibitor and bleeding tendency: can hormonal state explain the differences? Blood Advances. ISSN 2473-9529. 5(11), p. 2516¨C2517. doi: 10.1182/BLOODADVANCES.2021004651. Full text in Research Archive
• andersen, elisabeth; Mowinckel, Marie-Christine; Stavik, Benedicte; Sandset, Per Morten & Dugarte, Maria Eugenia Chollet (2021). High-throughput Screening for Pharmacological Enhancers of Mutated Factor VII Activity. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 5.
• Andresen, Marianne Seierstad; Sletten, Marit; Sandset, Per Morten; Iversen, Nina; Stavik, Benedicte & Tinholt, Mari (2021). Coagulation factor V (F5) is an estrogen-responsive gene in breast cancer cells. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 5.
• Stavik, Benedicte; Andresen, Marianne Seierstad; Holm, Sverre; Skjelland, Mona; Tinholt, Mari & Sandset, Per Morten [Show all 8 contributors for this article] (2021). Increased levels of coagulation factor V in atherosclerotic plaques - an immune regulated response? . Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 5.
• andersen, elisabeth; Dugarte, Maria Eugenia Chollet; Sletten, Marit; Stavik, Benedicte; Myklebust, Christiane Fillion & Skarpen, Ellen [Show all 11 contributors for this article] (2020). Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding. Blood. ISSN 0006-4971. 136. doi: 10.1182/blood-2020-139219.
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• Dugarte, Maria Eugenia Chollet; andersen, elisabeth; de la Morena-Barrio, Maria Eugenia; Bravo-Perez, Carlos; Mowinckel, Marie-Christine & Myklebust, Christiane Fillion [Show all 12 contributors for this article] (2020). Characterizing Coagulation FVII from iPSC-Hepatocytes-like Cells: Setting the Basis for Cell Therapy Development. Blood. ISSN 0006-4971. 136. doi: 10.1182/blood-2020-139211.
• Kakkos, Stavros K.; Gohel, Manjit; Baekgaard, Niels; Bauersachs, Rupert; Bellmunt-Montoya, Sergi & Black, Stephen A [Show all 16 contributors for this article] (2020). Editor's Choice ¨C European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis. European Journal of Vascular and Endovascular Surgery. ISSN 1078-5884. 61(1), p. 9¨C82. doi: 10.1016/j.ejvs.2020.09.023.
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• Schultz, Nina Haagenrud; Holme, P?l Andre; Henriksson, Carola; Mowinckel, Marie-Christine; Sandset, Per Morten & Bratseth, Vibeke [Show all 7 contributors for this article] (2019). The influence of rivaroxaban on markers of fibrinolysis and endothelial cell activation/injury in patients with venous thrombosis. Thrombosis Research. ISSN 0049-3848. 177, p. 154¨C156. doi: 10.1016/j.thromres.2019.03.010.
• Sacco, Simona; Merki-Feld, Gabriele S.; ?gidius, Karen Lehrmann; Bitzer, Johannes; Canonico, Marianne & Kurth, Tobias [Show all 15 contributors for this article] (2018). Correction to: Hormonal contraceptives and risk of ischemic stroke in women with migraine: A consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC) (Journal of Headache and Pain (2018) 18 (108) DOI: 10.1186/s10194-017-0815-1). The Journal of Headache and Pain. ISSN 1129-2369. 19(1). doi: 10.1186/s10194-018-0912-9.
• Stavik, Benedicte; Tinholt, Mari; Skjelland, Mona; Espevik, Terje; Sandset, Per Morten & Halvorsen, Bente [Show all 7 contributors for this article] (2018). Coagulation factors in human atherosclerotic plaques ¨C a potential link to inflammation?
• Andresen, Marianne Seierstad; Iversen, Nina; Tinholt, Mari; Myklebust, Christiane Filion; Stavik, Benedicte & Sandset, Per Morten [Show all 7 contributors for this article] (2017). Analysis of estrogen mediated expression of TFPI-2 by miRNAs in MCF-7 cells. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 1, p. 408¨C409.
• Cui, Xueyan; Skretting, Grethe; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A & Kanse, Sandip [Show all 8 contributors for this article] (2017). A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in breast cancer. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 1, p. 395¨C395.
• Stavik, Benedicte; Espada, Sandra; Holm, Sverre; Bjerkeli, Vigdis; Sandset, Per Morten & Dahl, Tuva B?rresdatter [Show all 11 contributors for this article] (2017). TFPI in human atherosclerotic plaques. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 1(s1).
• Dahm, Anders Erik A; Jacobsen, Eva-Marie; Jacobsen, Anne Flem; Skuterud Wik, Hilde & Sandset, Per Morten (2017). High complement C3 increases the risk for postnatal venous thrombosis.

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