FARM5150 – Applied pharmacokinetics and dosing in clinical practice
Course description
Course content
The course will provide you with in-depth knowledge on pharmacokinetic principles, including factors that affect absorption, distribution, metabolism and excretion (ADME) of drugs. The focus will be on how to integrate these principles when adapting and evaluating therapeutic drug dosing in clinical practice. During the course will you acquire in-depth knowledge on design of drug dosing schemes, and how doses may be adapted to individual patients, with especial focus on patient cohorts like elderly, children and critical ill patients.
Learning outcome
After completing the course:
- you will have in-depth knowledge about basic pharmacokinetic principles and how to calculate individual pharmacokinetic parameters and variables.
- you will have a broad knowledge base and understanding of individual variability in pharmacokinetic processes; including pharmacogenetics, drug-drug interactions, adherence and disease.
- you will be able to design and adapt both intravenous and oral dose regimens and have an in-depth knowledge on how to individualize the dosing to specific patients.
- you will have an understanding about the principles behind both pharmacokinetic population modeling and physiology-based modelling (PBPK), and being able to perform simple modeling yourself.
- you will know the background for how to perform therapeutic drug monitoring (TDM).
- you will have an overview of how to apply different dosing tools in the clinic.
Admission to the course
The course is mainly open to students who have been admitted to the 5-year Master`s Programme in Pharmacy at the Department?of Pharmacy, University of Oslo. In the event that space is available, other master`s level students may apply. Knowledge in relevant subject area corresponding to the content of Semester 1 through 7 at the department’s Master`s Programme in Pharmacy is required. For more information, please contact the Study Administration at the Department of Pharmacy, studieinfo@farmasi.uio.no.
Formal prerequisite knowledge
Passed the exam in:
- FARM1100 – Pharmaceutical Chemistry
- FARM1110 – Pharmacology, Physiology and Cell Biology 1
- FARM1120 – Social Pharmacy
- FARM1130 – Pharmaceutically Based Organic Chemistry
- FARM1140 – Pharmacology, Physiology and Cell Biology 2
- FARM1150 – Pharmaceutical Based Biochemistry
- FARM2100 – Medicinal Chemistry
- FARM2110 – Pharmacotherapy 1
- FARM2120 – Pharmaceutics and Biopharmaceutics
- FARM2130 – Pharmaceutical Analytical Chemistry
- FARM2140 – Pharmaceutical Microbiology
- FARM2150 – Formulation of Drugs and Quality Assurance in Drug Production
- FARM3100 – Pharmacognosy
- FARM3110 – Pharmacotherapy 2
- FARM3120 – Medicine Use and Public Health
- FARM3130 – Advanced Pharmacy Practice Experience (APPE)
- the compulsory HMS-courses HMS0501 – Safety and Physical Environment, HMS0502 – Positive Learning Environment, HMS0503 – Laboratory Safety, HMS0506 – Patient Clinic Safety and HMS0507 – Fire Safety required for students at the 5-year Master`s Programme in Pharmacy.
Approved the compulsory parts of:
- FARM4100 – Personalised Drug Therapy
- FARM4110 – Comprehensive Biopharmacy and Formulation Technology
- FARM4120 – Drug Development
Formal prerequisite knowledge for students admitted to Studiel?p for farmas?yter med mastergrad fra land utenfor EU/E?S:
- FARM4910K – Farmakoterapi og samfunnsfarmasi med fokus p? norske terapitradisjoner og norske forhold
- FARM4920K – Fra virkestoff til ferdig formulering med fokus p? avanserte legemiddelformer
- FARM4930K – Kvalitetssikring ved produksjon og klinisk utpr?vning av legemidler
- approved the compulsory HMS-courses HMS0501 – Safety and Physical Environment, HMS0502 – Positive Learning Environment, HMS0503 – Laboratory Safety, HMS0506 – Patient Clinic Safety and HMS0507 – Fire Safety required for students at the 5-year Master`s Programme in Pharmacy.
For students admitted to the 5-year Master`s Programme in Pharmacy until and including 2016 and who have been transferred from the old study plan, separate formal prerequisite knowledge apply. These are in professional compliance with the formal prerequisite knowledge that apply to the course, but may be replaced by courses from the old study plan, as well as transitional courses. Students on transitional arrangements may contact the study administration for a complete overview of the formal prerequisite knowledge required.
Overlapping courses
- 6 credits overlap with FRM5740 – Advanced Pharmacokinetics (discontinued).
- 6 credits overlap with FRM9740 – Videreg?ende farmakokinetikk (discontinued).
Teaching
- Lectures: ca. 6 hours
- Seminars: ca. 12 hours
- Colloquium: ca. 8 hours
The course may be cancelled if the number of enrolled students are low.
Examination
Final written exam, which counts 100?% towards the final?grade.?
Examination support material
Microsoft Office package.
Language of examination
The examination text is given in Norwegian. You may submit your response in Norwegian, Swedish or Danish. English on?request.
Grading scale
Grades are awarded on a scale from A to F, where A is the best grade and F?is a fail. Read more about the grading system.
Resit an examination
This course offers both postponed and resit of examination. Read more:
More about examinations at UiO
- Use of sources and citations
- Special exam arrangements due to individual needs
- Withdrawal from an exam
- Illness at exams / postponed exams
- Explanation of grades and appeals
- Resitting an exam
- Cheating/attempted cheating
You will find further guides and resources at the web page on examinations at UiO.